The Greek Islands are one of the Mediterranean's most compelling destinations, and with P&O Cruises sailing directly from Southampton in 2026, there is no airport queue standing between you and the voyage. At Cruise1st, one of the UK's leading cruise specialists, our experts help you choose the right cabin grade and fare inclusions for your trip — and through our Cruise1st Packages we can add hotels, transfers and insurance so the whole holiday sits on one booking. Call us before you commit and get genuine advice, not a search result.

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P&O Cruises operates a 19-night round-trip sailing to the Mediterranean and the Greek Islands, departing from and returning to Southampton in 2026. The sailing departs in the autumn, leaving you free to board at Southampton — no flight, no airport, no baggage carousel. Most of Britain can reach Southampton by road or rail, which makes this genuinely one of the most straightforward ways to reach the Greek Islands from the UK. If you are looking at Mediterranean cruises from Southampton in 2026 more broadly, this sailing sits squarely at the heart of what is on offer.
P&O Cruises is the cruise line operating this route, and the ship is Arcadia. P&O is one of the most familiar names in British cruising, with a reputation built on departures from UK home ports and a style that suits experienced cruisers who want a relaxed, sociable atmosphere. Arcadia sails exclusively for adults, which gives the ship a quieter tone than a family fleet.
The itinerary is a 19-night round trip, beginning and ending in Southampton, routing through the Mediterranean to reach the Greek Islands. Everything is included within the cruise fare; our team can advise which fare tier suits you best when you call.
Arcadia is a well-established adult-only ship with a range of spaces that suit both lively evenings and quieter days at sea. The Palladium is a 3-tier theatre at the heart of the ship’s evening entertainment, staging large-scale productions on a proper stage. For dining, Marco Pierre White’s Ocean Grill restaurant offers a white-tablecloth experience that goes well beyond the main dining rooms. If you want to unwind during sea days, Arcadia’s hydro-therapy pool provides a dedicated space for relaxation away from the open decks.
Choosing your cabin well is worth the time. Arcadia’s grades run from inside cabins through to full suites, and the difference between them on a 19-night sailing is significant. Here is a summary of the main options, ordered from the most affordable to the most spacious:
For a full breakdown of layouts and deck positions, see Arcadia’s cabins and deck plans.
Fares for this sailing start at £1,140 pp*. The sailing is currently reduced by up to 12% from the price previously listed for that cabin grade — and in this case that reduction applies to the sailing. If you are comparing fares, our team can talk you through which cabin grade gives you the best value for a voyage of this length.
P&O periodically makes fare types such as early-booking offers and last-minute reductions available, so it is worth asking our team what is current when you call.
Every sailing departs from Southampton, which means no flight is needed at any point in the holiday. Southampton is well served by road and rail from most parts of the UK, and because the ship returns to Southampton at the end of the 19 nights, the whole holiday is contained: you leave home, join the ship, and come back to the same port. There is no need to arrange a flight home from a foreign port, and no risk of a missed connection at the other end.
Through our Cruise1st Packages service, we can arrange a hotel in Southampton the night before departure, transfers to and from the port, and travel insurance — all on the same booking. If you are travelling from further afield, we can look at train options to Southampton too.
The departure falls in the autumn of 2026, which means you will spend the sea days and port calls in the eastern Mediterranean at that point in the year. If you are still weighing up timing, our team can help you think through what suits your schedule.
If the autumn sailing does not fit, it is worth looking at all P&O Cruises 2026 departures from Southampton for alternative routes and departure dates across the year. For those planning further ahead, P&O Cruises 2027 from Southampton has a wider range of sailings to consider.
If you are looking at Southampton departures more broadly in 2026, there is a good spread of options across the year. All 2026 cruises from Southampton covers every line and region departing from the port. For something shorter, mini cruises from Southampton in 2026 are worth a look if you want a short break closer to home. If the Mediterranean is the draw rather than a specific ship, Mediterranean cruises in 2026 gives you the full picture across departure ports and lines.
Fans of all-inclusive Mediterranean cruises in 2026 will find a range of fare options there, and if you are open to the wider region, Mediterranean cruises from the UK in 2026 covers departures beyond Southampton too. Those who prefer a fly-cruise to join a ship in the Mediterranean can browse Mediterranean fly-cruises in 2026.
For a different region entirely, Norwegian Fjords cruises in 2026 and British Isles cruises in 2026 are both popular from UK ports. If your travel window is towards the end of the year, all-inclusive Christmas cruises from Southampton in 2026 and all 2026 Christmas cruises are worth exploring.
For everything sailing from the port, all cruises from Southampton is the broadest starting point — and if you would like to browse the full range of cruises available across all destinations and departure ports, our team can help you narrow it down.
*Prices are per person based on 2 people sharing, and are subject to change. This price is not kept up to date and therefore does not reflect live pricing and availability. Prices and any discounts shown were checked on 14 October 2026.
Where a discount is shown, it is a reduction from the price previously listed for that cabin grade on that sailing, not a comparison between cabin grades or against a brochure rate. Discounts and prices shown are not kept up to date: the reduction available now may be smaller, or may have ended, and prices may have changed.
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Greek Islands Cruises from Southampton in 2026