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Panama Canal Cruises - Top Picks

This week, Cruise1st’s Top Picks spotlight the enchanting Panama Canal cruises, where you can delve into stunning landscapes and vibrant cultures. Experience the bustling charm of Colon, where the iconic Miraflores Locks reveal the engineering marvel of the Canal. Don’t miss a visit to the lush wonders of Gatun Lake, teeming with wildlife. Explore the historical allure of Panama City with its picturesque Casco Viejo district, filled with colourful colonial architecture. These trending adventures promise unforgettable memories among breathtaking vistas!

Panama Canal Cruises - Top Picks

Popular Filters

Departure Dates

Trip Duration

Cabin Category

Price

£

£

Trip price per person based on 2 persons trip

Destination

44

424

73

779

822

3294

880

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851

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Cruise lines

5

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2

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Ships

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Themes

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44 cruises

Central America from Miami, Florida with the Brilliant Lady

Virgin Voyages

Cruise Only

From Miami To Los Angeles

Brilliant Lady

Adults Only

Full board

All-Inclusive Ship

Dine Like a Rock Star

26 Mar 2027

16 nights

Inside

from

£1,585

pp

£1,865

Outside

from

£1,565

pp

£1,932

Balcony

from

£1,929

pp

£2,296

Suite

from

£6,904

pp

Best Price Guarantee

Learn more

Central America from Los Angeles, California with the Celebrity Summit

Celebrity Cruises

Cruise Only

From Los Angeles To Boston

Celebrity Summit

Family Friendly

Premium Cruise Line

from £41 – £72 off when you book online

18 Sep 2027

18 nights

No Alternative Dates

Inside

from

£2,030

pp

£2,160

Outside

from

£2,065

pp

£2,197

Balcony

from

£3,609

pp

£3,721

Central America from Tampa, Florida with the Celebrity Summit

Celebrity Cruises

Cruise Only

From Tampa To Los Angeles

Celebrity Summit

Family Friendly

Premium Cruise Line

from £49 – £88 off when you book online

18 Apr 2027

15 nights

No Alternative Dates

Inside

from

£2,428

pp

£3,073

Outside

from

£2,693

pp

£3,453

Balcony

from

£4,408

pp

£4,544

Central America from San Diego, California with the Serenade of the Seas

Royal Caribbean

Cruise Only

From San Diego To Tampa

Serenade of the Seas

Family Friendly

from £30 – £61 off when you book online

7 Oct 2027

15 nights

No Alternative Dates

Inside

from

£1,493

pp

Outside

from

£1,694

pp

Balcony

from

£3,028

pp

Picturesque Panama Canal and Latin American Charms

Cruise1st Package

Cruise with Flight, Hotel

From Los Angeles To Miami

Brilliant Lady

Adults Only

Full board

25 Nov 2027

20 nights

Inside

from

£2,499

pp

Outside

from

£2,599

pp

Balcony

from

£2,899

pp

Suite

from

£7,599

pp

£7,834

Central America from Los Angeles, California with the Brilliant Lady

Virgin Voyages

Cruise Only

From Los Angeles To Miami

Brilliant Lady

Adults Only

Full board

All-Inclusive Ship

Dine Like a Rock Star

29 Oct 2026

17 nights

Inside

from

£1,496

pp

Outside

from

£1,406

pp

Balcony

from

£1,535

pp

Suite

from

£7,207

pp

£7,749

Central America from Los Angeles, California with the Celebrity Summit

Celebrity Cruises

Cruise Only

From Los Angeles To Tampa

Celebrity Summit

Family Friendly

Premium Cruise Line

from £24 – £298 off when you book online

1 Oct 2026

17 nights

No Alternative Dates

Inside

from

£1,221

pp

Outside

from

£1,324

pp

£1,576

Balcony

from

£2,444

pp

The Retreat

from

£14,918

pp

Luxury Panama Canal and Southern Caribbean

Cruise1st Package

Cruise with Flight, Hotel

From / To Fort Lauderdale

Celebrity Ascent

All Inclusive

Family Friendly

New Ship

20 Nov 2026

15 nights

Inside

from

£3,099

pp

£3,297

Outside

from

£3,599

pp

Balcony

from

£4,099

pp

Southern Caribbean from Fort Lauderdale (Port Everglades), Florida with the Celebrity Ascent

Celebrity Cruises

Cruise Only

From / To Fort Lauderdale

Celebrity Ascent

Family Friendly

New Ship

Premium Cruise Line

from £27 – £239 off when you book online

23 Nov 2026

11 nights

Inside

from

£1,359

pp

£1,788

Outside

from

£2,045

pp

£2,108

Balcony

from

£2,368

pp

£2,441

The Retreat

from

£11,965

pp

£12,335

Caribbean from Fort Lauderdale (Port Everglades), Florida with the Celebrity Ascent

Celebrity Cruises

Cruise Only

From / To Fort Lauderdale

Celebrity Ascent

Family Friendly

New Ship

Premium Cruise Line

from £26 – £100 off when you book online

3 Jan 2028

11 nights

Inside

from

£1,304

pp

£1,516

Outside

from

£1,596

pp

£1,663

Balcony

from

£1,843

pp

£1,961

The Retreat

from

£5,023

pp

£5,909

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