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South America Cruises - Top Picks

Dive into the vibrant allure of South America with Cruise1st’s Top Picks for the week! Experience the rhythm of Rio de Janeiro, where the stunning beaches of Copacabana meet the iconic Sugarloaf Mountain. Explore the lush Amazon rainforest, teeming with exotic wildlife, or marvel at the breathtaking landscapes of Patagonia, from the jagged peaks of Los Glaciares National Park to the stunning vistas of Torres del Paine. Discover the gastronomic delights of Buenos Aires, making your cruise an unforgettable adventure!

View All South America Cruises
South America Cruises - Top Picks

Popular Filters

Departure Dates

Trip Duration

Cabin Category

Price

£

£

Trip price per person based on 2 persons trip

Destination

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763

399

74

767

838

3413

865

1779

836

3651

Cruise lines

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68

47

21

20

218

31

2

57

27

3

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34

32

32

Themes

​

134

42

52

1

2

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28

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118

10

24

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2

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16

105

21

11

763 cruises

Brazil from Rio de Janeiro, Brazil with the MSC Musica

MSC Cruises

Cruise Only

From / To Rio de Janeiro

MSC Musica

Full board

Tips

up to £60 off when you book online

2 Mar 2027

7 nights

Inside from

£534

pp

Was £593

Outside from

£651

pp

Was £723

Balcony from

£768

pp

Was £853

MSC Yacht Club from

£2,994

pp

Was £3,327

Best Price Guarantee

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Samba & Sea Breeze: Rio de Janeiro and Brazil’s Island Gems

Cruise1st Package

Cruise with Flight, Hotel

From / To Rio de Janeiro

MSC Musica

Full board

Tips

12 Feb 2027

12 nights

No Alternative Dates

Inside from

£1,869

pp

Outside from

£1,999

pp

Balcony from

£2,149

pp

MSC Yacht Club from

£3,199

pp

Iguazu Falls, Rio & Buenos Aires with All Inclusive South America Cruising

Cruise1st Package

Cruise with Flight, Hotel, Tours and excursions

From / To Buenos Aires

Celebrity Equinox

20 Feb 2027

22 nights

No Alternative Dates

Balcony from

£6,899

pp

Brazil from Santos, Brazil with the MSC Virtuosa

MSC Cruises

Cruise Only

From / To Santos (São Paulo)

MSC Virtuosa

Full board

Tips

up to £40 off when you book online

12 Dec 2026

7 nights

Inside from

£687

pp

Was £763

Outside from

£718

pp

Was £798

Balcony from

£811

pp

Was £901

Suite from

£1,463

pp

Was £1,626

MSC Yacht Club from

£2,019

pp

Was £2,243

South America from Rio de Janeiro, Brazil with the MSC Splendida

MSC Cruises

Cruise Only

From / To Rio de Janeiro

MSC Splendida

Full board

Tips

up to £40 off when you book online

10 Mar 2027

8 nights

Inside from

£751

pp

Was £834

Outside from

£880

pp

Was £978

Balcony from

£901

pp

Was £1,001

Suite from

£1,307

pp

Was £1,452

MSC Yacht Club from

£2,015

pp

Was £2,239

South America from Rio de Janeiro, Brazil with the MSC Splendida

MSC Cruises

Cruise Only

From / To Rio de Janeiro

MSC Splendida

Full board

Tips

29 Nov 2026

7 nights

No Alternative Dates

Balcony from

£867

pp

Was £963

South America from Rio de Janeiro, Brazil with the MSC Splendida

MSC Cruises

Cruise Only

From / To Rio de Janeiro

MSC Splendida

Full board

Tips

up to £49 off when you book online

17 Jan 2027

9 nights

Inside from

£952

pp

Was £1,058

Outside from

£1,089

pp

Was £1,210

Balcony from

£1,104

pp

Was £1,227

Suite from

£1,571

pp

Was £1,746

MSC Yacht Club from

£2,443

pp

Was £2,714

South America from Buenos Aires, Argentina with the MSC Splendida

MSC Cruises

Cruise Only

From / To Buenos Aires

MSC Splendida

Full board

Tips

from £20 – £47 off when you book online

11 Dec 2026

8 nights

Inside from

£1,001

pp

Was £1,112

Outside from

£1,219

pp

Was £1,354

Balcony from

£1,298

pp

Was £1,442

Suite from

£1,734

pp

Was £1,927

MSC Yacht Club from

£2,338

pp

Was £2,598

South America from Santiago de Chile, Chile with the Majestic Princess

Princess Cruises

Cruise Only

From Santiago de Chile To Buenos Aires

Majestic Princess

22 Dec 2026

15 nights

Inside from

£1,654

pp

Balcony from

£2,527

pp

Suite from

£2,499

pp

South America from Rio de Janeiro, Brazil with the MSC Splendida

MSC Cruises

Cruise Only

From / To Rio de Janeiro

MSC Splendida

Full board

Tips

up to £46 off when you book online

13 Feb 2027

9 nights

No Alternative Dates

Inside from

£883

pp

Was £981

Outside from

£1,020

pp

Was £1,133

Balcony from

£1,043

pp

Was £1,159

Suite from

£1,510

pp

Was £1,678

MSC Yacht Club from

£2,299

pp

Was £2,554

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