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South America Cruises - Top Picks

Dive into the vibrant allure of South America with Cruise1st’s Top Picks for the week! Experience the rhythm of Rio de Janeiro, where the stunning beaches of Copacabana meet the iconic Sugarloaf Mountain. Explore the lush Amazon rainforest, teeming with exotic wildlife, or marvel at the breathtaking landscapes of Patagonia, from the jagged peaks of Los Glaciares National Park to the stunning vistas of Torres del Paine. Discover the gastronomic delights of Buenos Aires, making your cruise an unforgettable adventure!

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South America Cruises - Top Picks

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Luxury South America with Buenos Aires Stay

Cruise1st Package

Luxury South America with Buenos Aires Stay

19 nights

From Buenos Aires to Buenos Aires

Celebrity Equinox

02/12/2025 - 21/12/2025

Cruise

Flight

Hotel

Inside

from £4,199 pp

Balcony

from £4,999 pp

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South America from Buenos Aires, Argentina with the MSC Fantasia

MSC Cruises

South America from Buenos Aires, Argentina with the MSC Fantasia

8 nights

From Buenos Aires to Buenos Aires

MSC Fantasia

Nov 2025 - Mar 20268 Sails

Cruise

Full board

Tips

Inside

from £706 pp

£767

Outside

from £937 pp

£1,018

Brazilian Brilliance

Cruise1st Package

Brazilian Brilliance

14 nights

From Buenos Aires to Rio de Janeiro

Marina

04/03/2026 - 18/03/2026

Cruise

Flight

Hotel

Wi-Fi

Full board

Tips

Inside

from £2,999 pp

Outside

from £3,499 pp

South America from Buenos Aires, Argentina with the Oosterdam

Holland America Line

South America from Buenos Aires, Argentina with the Oosterdam

22 nights

From Buenos Aires to San Antonio

Oosterdam

Dec 2025 - Jan 20273 Sails

Cruise

Inside

from £4,227 pp

£4,449

Outside

from £4,303 pp

£4,529

South America from Buenos Aires, Argentina with the Marina

Oceania Cruises

South America from Buenos Aires, Argentina with the Marina

12 nights

From Buenos Aires to Rio de Janeiro

Marina

10/01/2026 - 22/01/2026

Cruise

Wi-Fi

Full board

Tips

Inside

from £2,889 pp

Outside

from £3,529 pp

South America from Buenos Aires, Argentina with the MSC Preziosa

MSC Cruises

South America from Buenos Aires, Argentina with the MSC Preziosa

7 nights

From Buenos Aires to Buenos Aires

MSC Preziosa

Jan 2026 - Mar 20266 Sails

Cruise

Full board

Tips

Inside

from £542 pp

£589

Outside

from £652 pp

£709

South America from Santiago de Chile, Chile with the Sapphire Princess

Princess Cruises

South America from Santiago de Chile, Chile with the Sapphire Princess

16 nights

From Santiago de Chile to Buenos Aires

Sapphire Princess

06/12/2025 - 22/12/2025

Cruise

Inside

from £1,589 pp

£2,605

Outside

from £1,549 pp

£1,648

South America from Montevideo, Uruguay with the MSC Fantasia

MSC Cruises

South America from Montevideo, Uruguay with the MSC Fantasia

8 nights

From Montevideo to Montevideo

MSC Fantasia

Nov 2025 - Mar 20267 Sails

Cruise

Full board

Tips

Inside

from £772 pp

£839

Outside

from £949 pp

£1,032

South America from Buenos Aires, Argentina with the Celebrity Equinox

Celebrity Cruises

South America from Buenos Aires, Argentina with the Celebrity Equinox

8 nights

From Buenos Aires to Santos (São Paulo)

Celebrity Equinox

14/03/2026 - 22/03/2026

Cruise

Balcony

from £1,015 pp

The Retreat

from £3,012 pp

£3,502

South America from Santos, Brazil with the MSC Preziosa

MSC Cruises

South America from Santos, Brazil with the MSC Preziosa

7 nights

From Santos (São Paulo) to Santos (São Paulo)

MSC Preziosa

Jan 2026 - Mar 20268 Sails

Cruise

Full board

Tips

Inside

from £573 pp

£623

Outside

from £693 pp

£753

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    South America Cruises - Top Picks