South America Cruises - Top Picks
Dive into the vibrant allure of South America with Cruise1st’s Top Picks for the week! Experience the rhythm of Rio de Janeiro, where the stunning beaches of Copacabana meet the iconic Sugarloaf Mountain. Explore the lush Amazon rainforest, teeming with exotic wildlife, or marvel at the breathtaking landscapes of Patagonia, from the jagged peaks of Los Glaciares National Park to the stunning vistas of Torres del Paine. Discover the gastronomic delights of Buenos Aires, making your cruise an unforgettable adventure!
Stopover
Arrival port
16
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Themes
133
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758 cruises
Brazil from Rio de Janeiro, Brazil with the MSC Musica
Cruise Only
From / To Rio de Janeiro
MSC Musica
Full board
Tips
up to £37 off when you book online
2 Mar 2027
7 nights
Best Price Guarantee
Learn more
Samba & Sea Breeze: Rio de Janeiro and Brazil’s Island Gems
Cruise with Flight, Hotel
From / To Rio de Janeiro
MSC Musica
Full board
Tips
12 Feb 2027
12 nights
No Alternative Dates
Iguazu Falls, Rio & Buenos Aires with All Inclusive South America Cruising
Cruise with Flight, Hotel, Tours and excursions
From / To Buenos Aires
Celebrity Equinox
20 Feb 2027
22 nights
No Alternative Dates
Brazil from Santos, Brazil with the MSC Virtuosa
Cruise Only
From / To Santos (São Paulo)
MSC Virtuosa
Full board
Tips
up to £40 off when you book online
12 Dec 2026
7 nights
Luxury Patagonia & Cape Horn Discovery Cruise
Cruise with Flight, Hotel
From Santiago de Chile To Buenos Aires
Majestic Princess
4 Dec 2027
18 nights
No Alternative Dates
South America from Santiago de Chile, Chile with the Majestic Princess
Cruise Only
From Santiago de Chile To Buenos Aires
Majestic Princess
22 Dec 2026
15 nights
South America from Rio de Janeiro, Brazil with the MSC Splendida
Cruise Only
From / To Rio de Janeiro
MSC Splendida
Full board
Tips
up to £20 off when you book online
14 Dec 2026
8 nights
South America from Rio de Janeiro, Brazil with the MSC Splendida
Cruise Only
From / To Rio de Janeiro
MSC Splendida
Full board
Tips
29 Nov 2026
7 nights
No Alternative Dates
South America from Rio de Janeiro, Brazil with the MSC Splendida
Cruise Only
From / To Rio de Janeiro
MSC Splendida
Full board
Tips
from £20 – £46 off when you book online
13 Feb 2027
9 nights
No Alternative Dates
South America from Rio de Janeiro, Brazil with the MSC Splendida
Cruise Only
From / To Rio de Janeiro
MSC Splendida
Full board
Tips
up to £31 off when you book online
26 Jan 2027
9 nights