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South America Cruises - Top Picks

Dive into the vibrant allure of South America with Cruise1st’s Top Picks for the week! Experience the rhythm of Rio de Janeiro, where the stunning beaches of Copacabana meet the iconic Sugarloaf Mountain. Explore the lush Amazon rainforest, teeming with exotic wildlife, or marvel at the breathtaking landscapes of Patagonia, from the jagged peaks of Los Glaciares National Park to the stunning vistas of Torres del Paine. Discover the gastronomic delights of Buenos Aires, making your cruise an unforgettable adventure!

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South America Cruises - Top Picks

South America (733)
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South America from Buenos Aires, Argentina with the Celebrity Equinox

Celebrity Cruises

South America from Buenos Aires, Argentina with the Celebrity Equinox

14 nights

From Buenos Aires to Buenos Aires

Celebrity Equinox

Dec 2025 - Mar 20278 Sails

Cruise

Inside

from £1,038 pp

Outside

from £1,424 pp

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South America from Santos, Brazil with the MSC Preziosa

MSC Cruises

South America from Santos, Brazil with the MSC Preziosa

7 nights

From Santos (São Paulo) to Santos (São Paulo)

MSC Preziosa

Jan 2026 - Mar 20268 Sails

Cruise

Full board

Tips

Inside

from £573 pp

£623

Outside

from £693 pp

£753

South America from Buenos Aires, Argentina with the Oosterdam

Holland America Line

South America from Buenos Aires, Argentina with the Oosterdam

22 nights

From Buenos Aires to San Antonio

Oosterdam

Dec 2025 - Jan 20273 Sails

Cruise

Inside

from £4,227 pp

£4,449

Outside

from £4,303 pp

£4,529

South America from Buenos Aires, Argentina with the MSC Fantasia

MSC Cruises

South America from Buenos Aires, Argentina with the MSC Fantasia

8 nights

From Buenos Aires to Buenos Aires

MSC Fantasia

Nov 2025 - Mar 20268 Sails

Cruise

Full board

Tips

Inside

from £673 pp

£732

Outside

from £838 pp

£911

South America from Rio de Janeiro, Brazil with the Azamara Quest

Azamara

South America from Rio de Janeiro, Brazil with the Azamara Quest

8 nights

From Rio de Janeiro to Buenos Aires

Azamara Quest

31/01/2026 - 08/02/2026

Cruise

All Inclusive

Drinks

Tips

Inside

from £1,899 pp

£1,999

Outside

from £1,975 pp

£2,079

South America from Buenos Aires, Argentina with the MSC Preziosa

MSC Cruises

South America from Buenos Aires, Argentina with the MSC Preziosa

7 nights

From Buenos Aires to Buenos Aires

MSC Preziosa

Jan 2026 - Mar 20266 Sails

Cruise

Full board

Tips

Inside

from £542 pp

£589

Outside

from £652 pp

£709

Brazilian Brilliance

Cruise1st Package

Brazilian Brilliance

14 nights

From Buenos Aires to Rio de Janeiro

Marina

04/03/2026 - 18/03/2026

Cruise

Flight

Hotel

Wi-Fi

Full board

Tips

Inside

from £2,999 pp

Outside

from £3,499 pp

South America from Montevideo, Uruguay with the MSC Fantasia

MSC Cruises

South America from Montevideo, Uruguay with the MSC Fantasia

8 nights

From Montevideo to Montevideo

MSC Fantasia

Nov 2025 - Mar 20267 Sails

Cruise

Full board

Tips

Inside

from £772 pp

£839

Outside

from £949 pp

£1,032

South America from Santos, Brazil with the MSC Preziosa

MSC Cruises

South America from Santos, Brazil with the MSC Preziosa

7 nights

From Santos (São Paulo) to Santos (São Paulo)

MSC Preziosa

22/02/2026 - 01/03/2026

Cruise

Full board

Tips

Inside

from £619 pp

£673

Outside

from £739 pp

£803

South America from Buenos Aires, Argentina with the Majestic Princess

Princess Cruises

South America from Buenos Aires, Argentina with the Majestic Princess

15 nights

From Buenos Aires to Santiago de Chile

Majestic Princess

07/12/2026 - 22/12/2026

Cruise

Inside

from £2,219 pp

Balcony

from £2,929 pp

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    South America Cruises - Top Picks