Spain's coastline — from Barcelona's grand harbour to the sun-soaked ports of Alicante and Málaga — is among the most popular cruise destinations from the UK, and at Cruise1st you'll find sailings with all the major lines in one place. As one of the UK's leading cruise specialists, we help you choose the right cabin grade, the right fare inclusions and the right ship for your trip. Because every sailing here is one-way, ending in Spain, you'll need a flight home — and we can arrange that, along with hotels, transfers and insurance, as a single Cruise1st Package.
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14 cruises
England from Southampton, England with the MSC Euribia


Cruise Only
FREE Balcony Upgrade!
From Southampton, England To Las Palmas
MSC Euribia
Full board
Tips
2 Nov 2027
4 nights
No Alternative Dates
Best Price Guarantee
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Western Mediterranean from Southampton, England with the Queen Elizabeth


Cruise Only
Enjoy 10% off selected 2027 voyages
From Southampton, England To Barcelona
Queen Elizabeth
Full board
2 May 2027
12 nights
No Alternative Dates
Western Mediterranean from London (Dover), England, United Kingdom with the Carnival Sunshine


Cruise Only
From Dover To Barcelona
Carnival Sunshine
30 May 2027
10 nights
No Alternative Dates
Western Mediterranean from Portsmouth, England, United Kingdom with the Azamara Quest


Cruise Only
Up to US$750 Onboard Credit!
From Portsmouth To Tarragona
Azamara Quest
All Inclusive
Drinks
Tips
2 Sep 2028
21 nights
No Alternative Dates
Western Mediterranean from Southampton, England with the EXPLORA IV


Cruise Only
Unlimited Beverages, Complimentary Wi-Fi, Onboard Gratuities & More!
From Southampton, England To Barcelona
EXPLORA IV
All Inclusive
7 Oct 2028
14 nights
No Alternative Dates
Western Mediterranean from Southampton, England with the Balmoral


Cruise Only
From Southampton, England To Alicante
Balmoral
Full board
30 Sep 2027
7 nights
No Alternative Dates
Western Mediterranean from Portsmouth, England, United Kingdom with the Azamara Journey


Cruise Only
Up to US$750 Onboard Credit!
From Portsmouth To Barcelona
Azamara Journey
All Inclusive
Drinks
Tips
26 Aug 2028
20 nights
No Alternative Dates
Western Mediterranean from Southampton, England with the Balmoral


Cruise Only
From Southampton, England To Alicante
Balmoral
Full board
30 Sep 2027
16 nights
No Alternative Dates
Western Mediterranean from Southampton, England with the Seven Seas Mariner


Cruise Only
From Southampton, England To Barcelona
Seven Seas Mariner
All Inclusive
Drinks
Tips
30 Jul 2027
23 nights
No Alternative Dates
Canary Islands from Southampton, England with the MSC Euribia


Cruise Only
FREE Balcony Upgrade!
From Southampton, England To Santa Cruz de Tenerife
MSC Euribia
Full board
Tips
up to £23 off when you book online
2 Nov 2027
5 nights
No Alternative Dates
A cruise from the UK to Spain is one of the few holidays where the journey really is part of the experience. You board at Southampton, Dover or Portsmouth — all reachable by road or rail from most of Britain — and sail south, arriving in Barcelona, Alicante, Málaga or another Spanish port without ever boarding a plane. Because all sailings here are one-way, you’ll need to arrange a flight home from your disembarkation port; our team can book that, along with a hotel the night before, transfers and insurance, so it all comes together as one holiday rather than three separate bookings.
The Western Mediterranean dominates, with the bulk of sailings ending in or around Barcelona — Spain’s most popular disembarkation port for UK cruisers. From Barcelona you’re a short transfer from the airport, and the city rewards an extra night if your schedule allows. Other itineraries call at the sun-drenched Costa Blanca port of Alicante, the Moorish-influenced streets around Málaga, the Balearic capital Palma de Mallorca, the Roman ruins and wine culture of Tarragona, and the Santa Cruz de Tenerife gateway to the Canary Islands.
For those who want a longer voyage, a small number of sailings pass through Norway before heading south — a rewarding arc for anyone who wants fjords and Spanish sunshine on the same trip. One sailing traces the English coast before striking out for the Mediterranean. Whatever shape of itinerary appeals, our cruise search will surface the options across all lines and durations.
All sailings depart from English ports, so no fly-out is needed at the start of your holiday. Southampton is the dominant departure point, well served by road, rail and National Express coach. Dover offers convenient access for passengers coming from London and the South East. Portsmouth rounds out the options for those in Hampshire and West Sussex. Ask our team which port works best for where you’re travelling from — we can add a hotel the night before or a transfer from your door.
Several of the world’s most respected lines have sailings on this route. Here’s who is currently operating:
MSC Virtuosa, built in 2021, is MSC’s Meraviglia-Plus flagship and one of the most technically accomplished ships currently sailing from the UK. The ship is home to Rob — the world’s first humanoid robotic bartender at sea — and seven specialty restaurants, from the French-Vietnamese Indochine to the Kaito sushi venues and the Butcher’s Cut steakhouse. Kids head for the Savannah Aquapark while adults unwind beneath the 1,168 m² LED Galleria. Guests seeking extra privacy can book into the exclusive MSC Yacht Club, a ship-within-a-ship experience with dedicated spaces, butler service and priority boarding. Starlink internet runs throughout. See the full range of MSC Virtuosa cabins and deck plans before you choose your grade.
MSC Euribia is one of MSC’s newest ships and brings the same Meraviglia-class scale and entertainment to this route. Explore the full MSC Euribia cabins and deck plans to compare grades before booking.
Art deco design runs through every public space on Queen Elizabeth — glittering chandeliers, sweeping staircases and a grand lobby that evokes the golden age of ocean travel. The Royal Court Theatre stages West End-calibre productions, and Gala evenings in the Queens Room see guests dancing to a live orchestra. Dining is tiered across Britannia, Princess Grill and Queen’s Grill restaurants, and Cunard’s famous white-gloved afternoon tea is served daily. Cunard’s fare tiers offer genuine flexibility — from a Saver rate for those happy with an allocated stateroom, to a full Cunard Fare with priority upgrades, a low 15% deposit and the freedom to amend up to your balance due date. Review the Queen Elizabeth cabins and deck plans to find the grade that suits you best.
Pinnacle-class Nieuw Statendam is built around culture and cuisine. The dramatic two-storey Wine Tower anchors the main dining room, while the Tamarind pan-Asian restaurant — with its integrated 7-seat sushi bar — has been Holland America’s signature Asian dining venue since 2008. Music Walk gives guests 3 live music clubs in one corridor: Lincoln Center Stage classical performances, B.B. King’s Blues Club and Billboard Onboard. All 3 are included in the fare. Compare Nieuw Statendam cabins and deck plans when you’re ready to choose your stateroom.
Both Azamara ships carry just 694 guests — small enough to dock in boutique harbours that larger ships simply cannot reach, and to offer overnight and late-night port stays as standard. Specialty restaurants Prime C and Aqualina are included at no extra charge on Azamara Journey, alongside a Caviar and Champagne Bar. Both ships include the line’s signature AzAmazing Evenings: exclusive private cultural events ashore, from vineyard dinners to intimate concert performances. View Azamara Journey cabins and deck plans or Azamara Quest cabins and deck plans to see what’s available in each grade.
Carnival Sunshine brings Carnival’s lively, activity-packed style to the UK-to-Spain run. Browse the Carnival Sunshine cabins and deck plans to compare your options.
Across the ships on this route, you’ll find a full range of grades from interior rooms to full suites. On MSC Virtuosa, for example:
On Queen Elizabeth, grades run from the Britannia Inside cabin (around 19 m²) through ocean-view and balcony options to the Queens Grill Grand Suite Q1 — a 127 m² suite with approximately 90 m² of private balcony. See the full Queen Elizabeth cabin guide for every grade and deck.
Most sailings on this route are discounted — reductions are measured from the price previously listed for that cabin grade on that sailing. The typical saving sits around 10%, with the highest discount on any single departure reaching 22% pp*. That maximum applies to 1 departure; most reduced sailings are closer to the typical figure. Fare types such as Saver rates and last-minute offers also appear from time to time, so it pays to check back or speak to our team. Prices start from £324 pp*.
Because these are one-way sailings, you’ll disembark in Spain and need to make your own way home — unless we sort it for you. Our team can add return flights, a pre-cruise hotel near your departure port, transfers between airport and ship, guided shore tours and travel insurance, building everything into a single Cruise1st Package. It’s the difference between a cruise booking and a complete holiday, and it means one phone call covers everything. If you’d prefer to sail closer to home first, British Isles cruises from the UK are a good way to try ocean cruising without needing any flights at all, or browse adult-only cruises from the UK if you’re travelling as a couple or with friends.
If Spain is your gateway to a wider Mediterranean holiday, our Mediterranean cruises in 2027 and Mediterranean cruises from the UK in 2027 pages cover the full range of itineraries available from British ports. For shorter breaks, mini cruises from the UK in 2027 offer a taste of the sea without committing to a longer voyage, and all-inclusive no-fly sailings from Southampton in 2027 are worth a look if you’d like drinks and dining wrapped into the price. You can also browse all cruises from the UK or our full cruises search to explore every route and line in one place.
Rated 4.5/5 on Trustpilot from over 7,000 reviews, and backed by ABTA and ATOL protection, Cruise1st is one of the UK’s leading cruise specialists — with real cruise experts available by phone before you book.
*Prices are per person based on 2 people sharing, and are subject to change. This price is not kept up to date and therefore does not reflect live pricing and availability. Prices and any discounts shown were checked on 14 October 2026.
Where a discount is shown, it is a reduction from the price previously listed for that cabin grade on that sailing, not a comparison between cabin grades or against a brochure rate. Discounts and prices shown are not kept up to date: the reduction available now may be smaller, or may have ended, and prices may have changed.
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Cruises from the UK to Spain